Long-term deterioration in the mental health of healthcare workers (HCWs) has been reported during and after the COVID-19 pandemic. Determining the impact of COVID-19 incidence and mortality rates on the mental health of HCWs is essential to prepare for potential new pandemics. This study aimed to investigate the association of COVID-19 incidence and mortality rates with depressive symptoms over 2 years among HCWs in 20 countries during and after the COVID-19 pandemic.

Resumen IntroducciónUn nuevo tipo de coronavirus, denominado SARS-CoV-2, puede provocar patología respiratoria, denominada COVID-19, y ha generado una pandemia sin precedentes.Las complicaciones graves incluyen neumonía y la mortalidad oscila entre un 2 a un 5%.Hasta el 26 de marzo de 2020 la OMS informó 462 684 casos confirmados, y 20 834 muertes en todo el mundo.Se transmite por aerosoles o gotitas respiratorias.Distintas sociedades científicas han publicado guías de práctica clínica respecto a la atención oftalmológica en pandemia COVID-19.Cada una expone la información de manera diferente, lo que dificulta la toma de decisiones. MétodosRealizamos una búsqueda bibliográfica sensible en EMBASE y dirigida en sociedades oftalmológicas de guías de práctica clínica de atención oftalmológica en pandemia COVID-19.Extrajimos las recomendaciones, organizándolas en tres categorías: "qué pacientes tratar", "funcionamiento del policlínico y consulta", y "qué intervenciones evitar".En cada una se evaluó la búsqueda sistemática de evidencia y el uso

At the beginning of the COVID-19 pandemic in Chile, in March 2020, a projection indicated that a significant group of patients with pneumonia would require admission to an Intensive Care Unit and connection to a mechanical ventilator. Therefore, a paucity of these devices and other supplies was predicted. The initiative "Un respiro para Chile" brought together many people and institutions, public and private. In the course of three months, it allowed the design and building of several ventilatory assistance devices, which could be used in critically ill patients.

Student stress is a problem that hinders the teaching-learning processes, and that has increased considerably since the beginning of the Covid-19 pandemic. This article introduces a framework for the development of an emotion-based decision support tool for learning processes. As a case study, we consider undergraduate students starting their academic year virtually in the context of a pandemic. Through the application of the PANAS questionnaire and NLP techniques on free-text responses, students' emotions are automatically classified as positive and negative, as well as a level of basic emotions of the Plutchik model. The results allow to identify the most frequent sentiments in students. Also, they show concordances between both measurement instruments and a high capacity for the classification of emotions.

Seriously ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hospitalized in intensive care units (ICUs) are commonly given a combination of drugs, a process known as multi‐drug treatment. After extracting data on drug–drug interactions with clinical relevance from available online platforms, we hypothesize that an overall interaction map can be generated for all drugs administered. Furthermore, by combining this approach with simulations of cellular biochemical pathways, we may be able to explain the general clinical outcome. Finally, we postulate that by applying this strategy retrospectively to a cohort of patients hospitalized in ICU, a prediction of the timing of developing acute kidney injury (AKI) could be made. Whether or not this approach can be extended to other diseases is uncertain. Still, we believe it represents a valuable pharmacological insight to help improve clinical outcomes for severely ill patients.

COVID-19 pandemic disturbed mental health of healthcare personnel. Residents of the specialization programs could be at risk, since they were reassigned in their functions.To describe the impact of COVID-19 pandemic on symptoms of depression, stress, anxiety and resilient coping in residents of Anesthesiology, Internal Medicine and Emergency Medicine Material and Methods: Residents were invited to answer an online survey containing the DASS-21 scale for anxiety, stress and depression symptoms and the Brief Resilient Coping Scale (BRCS) for resilience skills.Fifty four out of 90 residents answered the survey. Eighteen to 24% of respondents had symptoms of depression, anxiety and stress at severe and extremely severe levels. Those with severe and extremely severe symptoms had also the lowest score on the BRCS resilience scale. We did not find an association between severity of symptoms and gender.A proportion of respondent residents had severe psychological symptoms and lower resilience scores during the COVID-19 pandemic.

Introducción: La actual pandemia provocada por SARS-CoV-2 ha provocado una alta carga en la salud pública y privada. Se han descrito casos y series de aspergilosis invasora asociada a pacientes con COVID-19 en ventilación mecánica.

Introducción: En el contexto del análisis de las repercusiones psicológicas, asociadas a la pandemia del COVID-19, especial importancia han alcanzado los estudios que informan altas tasas de depresión en la población general.

The results of mandatory confinement have been detrimental in several respects. Nonetheless, they have resulted in reducing the number of active cases of COVID-19. Chile has begun the de-escalation and needs to know the best time to end the restrictions.We discuss the best conditions and guarantees for the end of compulsory confinement.This study is based on a trend model with prediction estimation. The data of the variables of interest were subjected to linear regression studies to determine the curve that best explained the data. The coefficient of determination, the standard deviation of y in x, and the confidence interval of the observed curve were estimated. The trend curve was chosen in accordance with the regression estimates.It was found that all dependent variables tended to decrease over time in a quadratic fashion, except for the new cases variable. In general, the R2 and MAPE estimates are satisfactory, except for the variable number of PCR tests per day.Gradual and cautious steps should be taken before ending mandatory confinement. In the current de-escalator, daily PCR tests should be increased, maintaining vigilance on indicators of incidence, prevalence, and positivity of PCR tests. Evidence suggests with some degree of confidence that mandatory confinement could be safely lifted as of August 30, 2020. Long-term preparations must be made to contain future waves of new cases.Los resultados del confinamiento obligatorio han sido perjudiciales en varios aspectos. No obstante, han surtido efecto en lograr el descenso de casos activos de COVID-19. Chile ha comenzado la desescalada y precisa conocer el mejor momento para poner fin a las restricciones.Discutir las mejores condiciones y garantías para el fin del confinamiento obligatorio sobre la base de los casos nuevos, casos activos y positividad de exámenes de reacción en cadena de la polimerasa.Estudio basado en un modelo de tendencia con estimación de predicciones. Los datos de las variables de interés fueron sometidas a estudios de regresión lineal, con el objeto de determinar la curva que mejor explicaba los datos. Se estimó el coeficiente de determinación, la desviación estándar de y en x y el intervalo de confianza de la curva observada. Posteriormente, fue escogida la curva de tendencia en concordancia con las estimaciones de regresión.Se encontró que todas las variables dependientes tendían a disminuir con el tiempo de forma cuadrática, con excepción de la variable casos nuevos. En general, las estimaciones de coeficiente de determinación (R2) y error porcentual absoluto medio son satisfactorias, con excepción de la variable: número de exámenes de reacción en cadena de la polimerasa por día.Se deben tomar medidas graduales y cautelosas antes de poner fin al confinamiento obligatorio. En la actual desescalada, se deben aumentar los exámenes de reacción en cadena de la polimerasa diarios y mantener vigilancia en los indicadores de incidencia, prevalencia y positividad de dichos exámenes. La evidencia sugiere con cierto grado de confiabilidad que el confinamiento obligatorio podría levantarse de forma segura a contar del día 30 de agosto de 2020. Se deben hacer preparativos a largo plazo en contención de las futuras olas, es decir, una nueva alza de casos nuevos y activos luego del descenso.

The COVID-19 pandemic has impacted the mental health of healthcare workers. Studying the care perspective is essential to understanding the causes of specific mental health findings and proposing strategies to address them.