Avulsion of permanent teeth is one of the most serious dental injuries, and a prompt and correct emergency management is very important for the prognosis. The International Association of Dental Traumatology (IADT) has developed a consensus statement after a review of the dental literature and group discussions. Experienced researchers and clinicians from various specialties were included in the task group. The guidelines represent the current best evidence and practice based on literature research and professionals’ opinion. In cases where the data did not appear conclusive, recommendations were based on the consensus opinion or majority decision of the task group. Finally, the IADT board members were giving their opinion and approval. The primary goal of these guidelines is to delineate an approach for the immediate or urgent care of avulsed permanent teeth.

This study examines the role of coping strategies related to positive reappraisal versus other cognitive strategies (deliberate rumination) as mediators between life impact and posttraumatic growth in survivors of the military dictatorship in Chile between 1973 and 1990 (tortured political prisoners and family members of political prisoners executed and missing). Survey data from 251 political violence survivors were analyzed using the SPSS PROCESS macro for bootstrapping indirect effects (Hayes, 2013). Results indicated that positive reappraisal (or reframing) coping mediated the relationship between life impact and posttraumatic growth. A serial multiple mediation model indicates that in the life impact to growth moderation process, rumination must be followed by positive reappraisal to drive this growth. These findings suggest that positive reappraisal of the traumatic experience is essential to achieve growth reports. Implications of these more complex relations are discussed for both counseling interventions and further research.

Consider longitudinal observations across different subjects such that the underlying distribution is determined by a non-linear mixed-effects model. In this context, we look at the misclassification error rate for allocating future subjects using cross-validation, bootstrap algorithms (parametric bootstrap, leave-one-out, .632 and [Formula: see text]), and bootstrap cross-validation (which combines the first two approaches), and conduct a numerical study to compare the performance of the different methods. The simulation and comparisons in this study are motivated by real observations from a pregnancy study in which one of the main objectives is to predict normal versus abnormal pregnancy outcomes based on information gathered at early stages. Since in this type of studies it is not uncommon to have insufficient data to simultaneously solve the classification problem and estimate the misclassification error rate, we put special attention to situations when only a small sample size is available. We discuss how the misclassification error rate estimates may be affected by the sample size in terms of variability and bias, and examine conditions under which the misclassification error rate estimates perform reasonably well.

AbstractThe attraction effect shows that adding a third alternative to a choice set can alter preference between the original two options. For over 30 years, this simple demonstration of context dependence has been taken as strong evidence against a class of parsimonious value‐maximising models that evaluate alternatives independently from one another. Significantly, however, in previous demonstrations of the attraction effect alternatives are approximately equally valuable, so there was little consequence to the decision maker irrespective of which alternative was selected. Here we vary the difference in expected value between alternatives and provide the first demonstration that, although extinguished with large differences, this theoretically important effect persists when choice between alternatives has a consequence. We use this result to clarify the implications of the attraction effect, arguing that although it robustly violates the assumptions of value‐maximising models, it does not eliminate the possibility that human decision making is optimal. © 2016 The Authors Journal of Behavioral Decision Making Published by John Wiley & Sons Ltd.

The majority of rocky reef fishes have complex life cycles, involving transition from a pelagic to a benthic environment. This means that as they grow, their morphology, behaviour and feeding habits must change. Therefore, shape changes occurring during early development of these fishes will be related to diet changes. The clingfish Sicyases sanguineus was selected for this study, because it displays a noticeable variation in shape from pelagic larvae to juvenile stage, and it is expected that diet composition will change as well. The pattern of shape changes was studied using geometric morphometrics. A set of 9 landmarks were digitized in 159 larval and juvenile fish and the same specimens were used for gut content analysis. Allometric growth was most prominent early in the ontogeny, from 4 to 12 mm. Morphology changed from a thin and hydrodynamic shape to a more robust and deeper body prior to settlement. The diet of the clingfish during larval stages showed preferences for a variety of copepod stages. As individual grows the ingested prey volume increases, but not the number and width of prey. A partial least square analysis showed low covariance between shape changes and diet composition changes in prey number and volume, suggesting that the two processes were temporally decoupled. The biggest shape changes, a lengthening of the visceral cavity and a flattening of the head, occurred up to 12 mm standard length, while the largest feeding differentiation, shifting from copepods to microalgae, occurred after 16 mm. Results suggest that shape changes precede trophic changes in this clingfish species during the transition from a pelagic to a benthic habitat.

AbstractFar‐field tsunami records from the Japanese tide gauge network allow the reexamination of the moment magnitudes (Mw) for the 1906 and 1922 Chilean earthquakes, which to date rely on limited information mainly from seismological observations alone. Tide gauges along the Japanese coast provide extensive records of tsunamis triggered by six great (Mw >8) Chilean earthquakes with instrumentally determined moment magnitudes. These tsunami records are used to explore the dependence of tsunami amplitudes in Japan on the parent earthquake magnitude of Chilean origin. Using the resulting regression parameters together with tide gauge amplitudes measured in Japan we estimate apparent moment magnitudes of Mw 8.0–8.2 and Mw 8.5–8.6 for the 1906 central and 1922 north‐central Chile earthquakes. The large discrepancy of the 1906 magnitude estimated from the tsunami observed in Japan as compared with those previously determined from seismic waves (Ms 8.4) suggests a deeper than average source with reduced tsunami excitation. A deep dislocation along the Chilean megathrust would favor uplift of the coast rather than beneath the sea, giving rise to a smaller tsunami and producing effects consistent with those observed in 1906. The 1922 magnitude inferred from far‐field tsunami amplitudes appear to better explain the large extent of damage and the destructive tsunami that were locally observed following the earthquake than the lower seismic magnitudes (Ms 8.3) that were likely affected by the well‐known saturation effects. Thus, a repeat of the large 1922 earthquake poses seismic and tsunami hazards in a region identified as a mature seismic gap.

The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery.

ABSTRACT We conduct a multiwavelength continuum variability study of the Seyfert 1 galaxy NGC 5548 to investigate the temperature structure of its accretion disk. The 19 overlapping continuum light curves ( to ) combine simultaneous Hubble Space Telescope, Swift, and ground-based observations over a 180 day period from 2014 January to July. Light-curve variability is interpreted as the reverberation response of the accretion disk to irradiation by a central time-varying point source. Our model yields the disk inclination , temperature K at 1 light day from the black hole, and a temperature–radius slope ( ) of . We also infer the driving light curve and find that it correlates poorly with both the hard and soft X-ray light curves, suggesting that the X-rays alone may not drive the ultraviolet and optical variability over the observing period. We also decompose the light curves into bright, faint, and mean accretion-disk spectra. These spectra lie below that expected for a standard blackbody accretion disk accreting at .

Abstract We use single-epoch spectroscopy of three gravitationally lensed quasars, HE 0435-1223, WFI 2033-4723, and HE 2149-2745, to study their inner structure (broad-line region [BLR] and continuum source). We detect microlensing-induced magnification in the wings of the broad emission lines of two of the systems (HE 0435-1223 and WFI 2033-4723). In the case of WFI 2033-4723, microlensing affects two “bumps” in the spectra that are almost symmetrically arranged on the blue (coincident with an Al iii emission line) and red wings of C iii]. These match the typical double-peaked profile that follows from disk kinematics. The presence of microlensing in the wings of the emission lines indicates the existence of two different regions in the BLR: a relatively small one with kinematics possibly related to an accretion disk, and another one that is substantially more extended and insensitive to microlensing. There is good agreement between the estimated size of the region affected by microlensing in the emission lines, lt-day (red wing of C iv in HE 0435-1223) and lt-day (C iii] bumps in WFI 2033-4723), and the sizes inferred from the continuum emission, lt-day (HE 0435-1223) and lt-day (WFI 2033-4723). For HE 2149-2745 we measure an accretion disk size lt-day. The estimates of p, the exponent of the size versus wavelength ( ), are 1.2 ± 0.6, 0.8 ± 0.2, and 0.4 ± 0.3 for HE 0435-1223, WFI 2033-4723, and HE 2149-2745, respectively. In conclusion, the continuum microlensing amplitude in the three quasars and chromaticity in WFI 2033-4723 and HE 2149-2745 are below expectations for the thin-disk model. The disks are larger and their temperature gradients are flatter than predicted by this model.

Problem Women with antiphospholipid antibodies (aPLs) present a risk of pregnancy morbidity (PM), vascular thrombosis (VT), or both (PM/VT). aPLs affect trophoblast function, and the aim of this study was to determine the modulation of this aPL-induced damage by different drugs. Method of study IgG was obtained from women with PM and PM/VT positive to aPLs. Binding of IgG to trophoblastic cells, proliferation, mitochondrial membrane integrity, and trophoblast invasion were assessed. The effect of enoxaparin, aspirin, and aspirin-triggered lipoxin (ATL) were evaluated as well as signal transducer and activator of transcription 3 (STAT3) phosphorylation. Results IgG from women with aPLs strongly binds to trophoblastic cells. Integrity of mitochondrial membrane was reduced, and proliferation was increased by IgG-PM/VT. Both IgG-PM and IgG-PM/VT decreased trophoblast invasion, which was restored by enoxaparin, aspirin, and ATL. IgG-PM triggered reduction in STAT3 phosphorylation.

AbstractTo what extent can the mammalian visual system be shaped by visual behavior? Here we analyze the shape of the visual fields, the densities and distribution of cells in the retinal ganglion-cell layer and the organization of the visual projections in two species of facultative non-strictly subterranean rodents, Spalacopus cyanus and Ctenomys talarum, aiming to compare these traits with those of phylogenetically closely related species possessing contrasting diurnal/nocturnal visual habits. S. cyanus shows a definite zone of frontal binocular overlap and a corresponding area centralis, but a highly reduced amount of ipsilateral retinal projections. The situation in C. talarum is more extreme as it lacks of a fronto-ventral area of binocular superposition, has no recognizable area centralis and shows no ipsilateral retinal projections except to the suprachiasmatic nucleus. In both species, the extension of the monocular visual field and of the dorsal region of binocular overlap as well as the whole set of contralateral visual projections, appear well-developed. We conclude that these subterranean rodents exhibit, paradoxically, diurnal instead of nocturnal visual specializations, but at the same time suffer a specific regression of the anatomical substrate for stereopsis. We discuss these findings in light of the visual ecology of subterranean lifestyles.

Cold allodynia is a common symptom of neuropathic and inflammatory pain following peripheral nerve injury. The mechanisms underlying this disabling sensory alteration are not entirely understood. In primary somatosensory neurons, cold sensitivity is mainly determined by a functional counterbalance between cold-activated TRPM8 channels and Shaker-like Kv1.1–1.2 channels underlying the excitability brake current IKD. Here we studied the role of IKD in damage-triggered painful hypersensitivity to innocuous cold. We found that cold allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in mice, was related to both an increase in the proportion of cold-sensitive neurons (CSNs) in DRGs contributing to the sciatic nerve, and a decrease in their cold temperature threshold. IKD density was reduced in high-threshold CSNs from CCI mice compared with sham animals, with no differences in cold-induced TRPM8-dependent current density. The electrophysiological properties and neurochemical profile of CSNs revealed an increase of nociceptive-like phenotype among neurons from CCI animals compared with sham mice. These results were validated using a mathematical model of CSNs, including IKD and TRPM8, showing that a reduction in IKD current density shifts the thermal threshold to higher temperatures and that the reduction of this current induces cold sensitivity in former cold-insensitive neurons expressing low levels of TRPM8-like current. Together, our results suggest that cold allodynia is largely due to a functional downregulation of IKD in both high-threshold CSNs and in a subpopulation of polymodal nociceptors expressing TRPM8, providing a general molecular and neural mechanism for this sensory alteration. La alodinia fría es un síntoma común de dolor neuropático e inflamatorio después de una lesión de los nervios periféricos. Los mecanismos que subyacen a esta alteración sensorial incapacitante no se comprenden del todo. En las neuronas somatosensoriales primarias, la sensibilidad al frío está determinada principalmente por un contrapeso funcional entre los canales TRPM8 activados en frío y los canales Kv1.1-1.2 similares a Shaker que subyacen a la corriente de freno de excitabilidad IKD. Aquí estudiamos el papel de laKD en la hipersensibilidad dolorosa desencadenada por el daño al frío inocuo. Encontramos que la alodinia fría inducida por la lesión crónica por constricción (CCI) del nervio ciático en ratones, se relacionó tanto con un aumento en la proporción de neuronas sensibles al frío (CSN) en los GRD que contribuyen al nervio ciático, como con una disminución en su umbral de temperatura fría. La densidad deKD se redujo en los CSN de alto umbral de ratones CCI en comparación con los animales simulados, sin diferencias en la densidad de corriente dependiente de TRPM8 inducida por frío. Las propiedades electrofisiológicas y el perfil neuroquímico de las CSN revelaron un aumento del fenotipo nociceptivo entre las neuronas de los animales CCI en comparación con los ratones simulados. Estos resultados se validaron utilizando un modelo matemático de CSNs, incluyendo IKD y TRPM8, mostrando que una reducción en la densidad de corriente de IKD desplaza el umbral térmico a temperaturas más altas y que la reducción de esta corriente induce sensibilidad al frío en neuronas previamente insensibles al frío que expresan bajos niveles de corriente similar a TRPM8. En conjunto, nuestros resultados sugieren que la alodinia fría se debe en gran medida a una regulación funcional a la baja de IKD tanto en CSN de alto umbral como en una subpoblación de nociceptores polimodales que expresan TRPM8, lo que proporciona un mecanismo molecular y neuronal general para esta alteración sensorial.

We describe a seiche process based on current, temperature, and sea-level data obtained from the Reloncaví fjord (41.6° S, 72.5° W) in southern Chile. We combined 4 months of acoustic Doppler current profiler (ADCP) data with sea-level, temperature, and wind time series to analyze the dynamics of low-frequency (periods > 1 day) internal oscillations in the fjord. Additionally, seasonal conductivity, temperature, and depth (CTD) data from 19 along-fjord stations were used to characterize the seasonality of the density field. The density profiles were used to estimate the internal long-wave phase speed (c) using two approximations: (1) a simple reduced gravity model (RGM) and (2) a continuously stratified model (CSM). No major seasonal changes in c were observed using either approximation (e.g., the CSM yielded 0.73 < c < 0.87 m s−1 for mode 1). The natural internal periods (TN) were estimated using Merian's formula for a simple fjord-like basin and the above phase speeds. Estimated values of TN varied between 2.9 and 3.5 days and were highly consistent with spectral peaks observed in the along-fjord currents and temperature time series. We conclude that these oscillations were forced by the wind stress, despite the moderate wind energy. Wind conditions at the end of winter gave us an excellent opportunity to explore the damping process. The observed damping time (Td) was relatively long (Td =  9.1 days).

Abstract Submillimeter galaxies (SMGs) at are luminous in the far-infrared, and have star formation rates, SFR, of hundreds to thousands of solar masses per year. However, it is unclear whether they are true analogs of local ULIRGs or whether the mode of their star formation is more similar to that in local disk galaxies. We target these questions by using Herschel-PACS to examine the conditions in the interstellar medium (ISM) in far-infrared luminous SMGs at –4. We present 70–160 μm photometry and spectroscopy of the [O iv]26 μm, [Fe ii]26 μm, [S iii]33 μm, [Si ii]34 μm, [O iii]52 μm, [N iii]57 μm, and [O i]63 μm fine-structure lines and the S(0) and S(1) hydrogen rotational lines in 13 lensed SMGs identified by their brightness in early Herschel data. Most of the 13 targets are not individually spectroscopically detected; we instead focus on stacking these spectra with observations of an additional 32 SMGs from the Herschel archive—representing a complete compilation of PACS spectroscopy of SMGs. We detect [O i]63 μm, [Si ii]34 μm, and [N iii]57 μm at in the stacked spectra, determining that the average strengths of these lines relative to the far-IR continuum are , , and , respectively. Using the [O iii]52 μm/[N iii]57 μm emission line ratio, we show that SMGs have average gas-phase metallicities . By using PDR modeling and combining the new spectral measurements with integrated far-infrared fluxes and existing [C ii]158 μm data, we show that SMGs have average gas densities, n, of and FUV field strengths, (in Habing units: ), consistent with both local ULIRGs and lower luminosity star-forming galaxies.

Here we describe modified syntheses of o-acetylbenzoic acids­ and o-acetylphenylacetic acids by Heck palladium-catalysed aryl­ation of n-butyl vinyl ether with o-iodobenzoic acids or with o-iodo­phenylacetic acids, respectively. General syntheses of benzo[b]naphtho[2,3-b]furan-6,11-diones from o-acetylbenzoic acids and 2-benzyl-3-hydroxynaphthalene-1,4-diones from o-acetylphenylacetic acids are also reported.

The β3 adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only available drug on the market that targets this receptor approved for the treatment of overactive bladder. However, the FDA (Food and Drug Administration) in USA and the MHRA (Medicines and Healthcare products Regulatory Agency) in UK have made reports of potentially life-threatening side effects associated with the administration of Mirabegron, casting doubts on the continuity of this compound. Therefore, it is of utmost importance to gather information for the rational design and synthesis of new β3 adrenergic ligands. Herein, we present the first combined 2D-QSAR (two-dimensional Quantitative Structure-Activity Relationship) and 3D-QSAR/CoMSIA (three-dimensional Quantitative Structure-Activity Relationship/Comparative Molecular Similarity Index Analysis) study on a series of potent β3 adrenergic agonists of indole-alkylamine structure. We found a series of changes that can be made in the steric, hydrogen-bond donor and acceptor, lipophilicity and molar refractivity properties of the compounds to generate new promising molecules. Finally, based on our analysis, a summary and a regiospecific description of the requirements for improving β3 adrenergic activity is given.

Abstract We present the results of an optical spectroscopic monitoring program targeting NGC 5548 as part of a larger multiwavelength reverberation mapping campaign. The campaign spanned 6 months and achieved an almost daily cadence with observations from five ground-based telescopes. The Hβ and He ii λ4686 broad emission-line light curves lag that of the 5100 Å optical continuum by and , respectively. The Hβ lag relative to the 1158 Å ultraviolet continuum light curve measured by the Hubble Space Telescope is ∼50% longer than that measured against the optical continuum, and the lag difference is consistent with the observed lag between the optical and ultraviolet continua. This suggests that the characteristic radius of the broad-line region is ∼50% larger than the value inferred from optical data alone. We also measured velocity-resolved emission-line lags for Hβ and found a complex velocity-lag structure with shorter lags in the line wings, indicative of a broad-line region dominated by Keplerian motion. The responses of both the Hβ and He ii emission lines to the driving continuum changed significantly halfway through the campaign, a phenomenon also observed for C iv, Lyα, He ii(+O iii]), and Si iv(+O iv]) during the same monitoring period. Finally, given the optical luminosity of NGC 5548 during our campaign, the measured Hβ lag is a factor of five shorter than the expected value implied by the R BLR–L AGN relation based on the past behavior of NGC 5548.

During the 1980s, the study of social movements became a central element of Chilean social thought. In the context of the struggle against the dictatorship, the forms of organization and protest deployed by the popular sectors attracted the attention of academics and politicians in an attempt to determine their nature and democratizing potential. Hegemonic sociology concluded that social movements did not exist in Chile and that social mobilizations had to be subordinate to the strategy of political parties, thereby bestowing a “scientific” status on the social-political divide. In the 1990s, with the end of the dictatorship, those sociologists abandoned the study of social movements. Only social history persisted in the understanding of the formation of popular subjectivities, contributing tools for characterizing the popular realm and the most recent outbreaks of protest and mobilization. El estudio de los movimientos sociales se constituyó como un eje central del pensamiento social chileno en la década de los ochenta. En el contexto de la lucha contra la dictadura, las formas de organización y de protesta desplegadas por los sectores populares concitaron la atención de académicos y políticos, en aras de establecer su carácter y potencialidad democratizadora. La sociología hegemónica concluyó que no existían movimientos sociales en Chile, y que las movilizaciones sociales debían subordinarse a la estrategia de los partidos políticos, dotando de “cientificidad” la escisión entre lo social y lo político. En los noventa, con el fin de la dictadura, aquellos sociólogos abandonaron el estudio de los movimientos sociales. Sólo la historia social perseveró en la comprensión de la constitución de las subjetividades populares, aportando herramientas para la caracterización del mundo popular y de los más recientes estallidos de protesta y movilización.

Abstract We use deep multi-epoch near-IR images of the VISTA Variables in the Vía Láctea (VVV) Survey to search for RR Lyrae stars toward the Southern Galactic plane. Here, we report the discovery of a group of RR Lyrae stars close together in VVV tile d025. Inspection of the VVV images and PSF photometry reveals that most of these stars are likely to belong to a globular cluster that matches the position of the previously known star cluster FSR 1716. The stellar density map of the field yields a >100σ detection for this candidate globular cluster that is centered at equatorial coordinates R.A. J2000 = 16:10:30.0, decl. J2000 = −53:44:56 and galactic coordinates l = 329.77812, b = −1.59227. The color–magnitude diagram of this object reveals a well-populated red giant branch, with a prominent red clump at K s = 13.35 ± 0.05, and J − K s = 1.30 ± 0.05. We present the cluster RR Lyrae positions, magnitudes, colors, periods, and amplitudes. The presence of RR Lyrae indicates an old globular cluster, with an age >10 Gyr. We classify this object as an Oosterhoff type I globular cluster, based on the mean period of its RR Lyrae type ab, days, and argue that this is a relatively metal-poor cluster with [Fe/H] = −1.5 ± 0.4 dex. The mean extinction and reddening for this cluster are and E(J − K s ) = 0.72 ± 0.02 mag, respectively, as measured from the RR Lyrae colors and the near-IR color–magnitude diagram. We also measure the cluster distance using the RR Lyrae type ab stars. The cluster mean distance modulus is (m − M)0 = 14.38 ± 0.03 mag, implying a distance D = 7.5 ± 0.2 kpc and a Galactocentric distance R G = 4.3 kpc.

Abstract We investigate the far-infrared (far-IR) properties of galaxies selected via deep, narrow-band imaging of the Hα emission line in four redshift slices from over ∼1 deg2 as part of the High-redshift Emission Line Survey (HiZELS). We use a stacking approach in the Herschel PACS/SPIRE far-IR bands, along with imaging from SCUBA-2 and Very Large Array 1.4 GHz imaging, to study the evolution of the dust properties of Hα-emitters selected above an evolving characteristic luminosity threshold, . We investigate the relationship between the dust temperatures, T dust, and the far-infrared luminosities, L IR, of our stacked samples, finding that our Hα-selection identifies cold, low-L IR galaxies ( K; ) at z = 0.40, and more luminous, warmer systems ( K; ) at z = 2.23. Using a modified graybody model, we estimate “characteristic sizes” for the dust-emitting regions of Hα-selected galaxies of ∼0.5 kpc, nearly an order of magnitude smaller than their stellar continuum sizes, which may provide indirect evidence of clumpy interstellar medium structure. Lastly, we use measurements of the dust masses from our far-IR stacking along with metallicity-dependent gas-to-dust ratios ( ) to measure typical molecular gas masses of for these bright Hα-emitters. The gas depletion timescales are shorter than the Hubble time at each redshift, suggesting probable replenishment of their gas reservoirs from the intergalactic medium. Based on the number density of Hα-selected galaxies, we find that typical star-forming galaxies brighter than comprise a significant fraction (35 ± 10%) of the total gas content of the universe, consistent with the predictions of the latest state-of-the-art cosmological simulations.